特纳综合征女性的子宫长度反映了初潮后的每日雌激素剂量。
The uterine length in women with Turner syndrome reflects the postmenarcheal daily estrogen dose.
作者信息
Snajderova Marta, Mardesic Tonko, Lebl Jan, Gerzova Hedvika, Teslik Leos, Zapletalova Jirina
机构信息
Endocrine Unit, 2nd Department of Paediatrics, 2nd Faculty of Medicine, University Hospital Motol, Prague, Czech Republic.
出版信息
Horm Res. 2003;60(4):198-204. doi: 10.1159/000073233.
AIM
To evaluate the effects of estrogen substitution on the uterine development in patients with Turner syndrome.
METHOD
57 women, aged 18.1-41.5 years, were treated with estrogen from puberty induction.
RESULTS
In 21 women (37%), the uterus developed to >65 mm in length. The daily estrogen dose correlated with both uterine length (r = 0.29; p < 0.05) and Tanner breast stage (r = 0.44; p < 0.001). A negative correlation between age at artificial menarche and uterine length was found (r = -0.29; p < 0.05). The endometrium thickness was greater in women with an uterus length >65 mm (p < 0.05). In 50% of the women (18 were evaluated), an adult-shaped uterus developed. Previous growth hormone therapy (n = 32) had no impact on the uterus length.
CONCLUSIONS
The uterine development was suboptimal in most patients. Further investigation is needed to optimize estrogen therapy for uterine development in patients with Turner syndrome.
目的
评估雌激素替代疗法对特纳综合征患者子宫发育的影响。
方法
对57名年龄在18.1至41.5岁之间的女性从青春期开始进行雌激素治疗。
结果
21名女性（37%）子宫长度发育至大于65毫米。每日雌激素剂量与子宫长度（r = 0.29；p < 0.05）以及坦纳乳房分期（r = 0.44；p < 0.001）均相关。人工初潮年龄与子宫长度呈负相关（r = -0.29；p < 0.05）。子宫长度大于65毫米的女性子宫内膜厚度更大（p < 0.05）。50%的女性（评估了18名）发育出成人形态的子宫。既往生长激素治疗（n = 32）对子宫长度无影响。
结论
大多数患者的子宫发育未达最佳状态。需要进一步研究以优化特纳综合征患者子宫发育的雌激素治疗方案。
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