Woldag Hartwig, Hummelsheim Horst
Neurologisches Rehabilitationszentrum Leipzig, Universität Leipzig, Leipzig, Germany.
Eur Neurol. 2003;50(3):165-71. doi: 10.1159/000073058.
To determine the functional benefit of botulinum toxin A (BtxA) in spasticity of arm flexors, we conducted an open-label study with 10 stroke patients. 480 mouse units BtxA (Dysport((R))) were injected into flexor muscles. Outcome measures were done by the Modified Ashworth Scale, Rivermead Motor Assessment (arm section), active and passive ranges of motion (ROM), grip strength and a 3-dimensional motion analysis. The functional capacity of the entire arm, even of the shoulder, and the ROM of fingers and wrist increased. Despite a diminution of muscle tone, grip strength remained unchanged or increased. An improvement of forearm extension was only observed in cases of preserved voluntary extensor motricity. Injection of BtxA into spastic distal flexor muscles may lead to a functional improvement of the entire arm. Grip strength is not necessarily reduced.
为确定A型肉毒毒素（BtxA）对臂部屈肌痉挛的功能益处，我们对10名中风患者进行了一项开放标签研究。将480鼠单位的BtxA（Dysport((R))）注射到屈肌中。通过改良Ashworth量表、Rivermead运动评估（手臂部分）、主动和被动活动范围（ROM）、握力以及三维运动分析来进行结果测量。整个手臂甚至肩部的功能能力以及手指和手腕的ROM均有所增加。尽管肌张力降低，但握力保持不变或增加。仅在保留自愿性伸肌运动的情况下观察到前臂伸展有所改善。将BtxA注射到痉挛性远端屈肌中可能会导致整个手臂的功能改善。握力不一定会降低。
