Mao Manjun, Yang Zhongduo, Jia Zhongjian
Department of Chemistry, National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, PR China.
Planta Med. 2003 Aug;69(8):745-9. doi: 10.1055/s-2003-42793.
One known eremophilanolide, 3beta-angeloyloxy-8beta,10beta-dihydroxy-6beta-methoxyeremophilenolide (1) and seven new eremophiane sesquiterpenes, 3beta-angeloyloxy-6beta-ethoxy-8beta,10beta-dihydroxyeremophilenolide (2), 3beta,6beta-diangeloyloxy-10alpha-hydroxy-8alpha-methoxyeremophilenolide, 6beta-angeloyloxy-8beta,10beta-dihydroxy-3-oxo-eremophilenolide, 6beta,8beta,10beta-trihydroxy-3-oxo-eremophilenolide, 3beta-angeloyloxy-6beta,10beta-dihydroxy-eremophila-7(11),8(9)-dien-8,12-olide (6), 3beta-angeloyloxy-10beta-hydroxy-6beta-methoxy-eremophila-7(11),8(9)-dien-8,12-olide, 3beta-angeloyloxy-8-oxo-eremophila-6.9-dien-12-oic acid ethyl ester, were isolated from the roots of Cacalia ainsliaeflora. Their structures were elucidated by spectroscopic methods. Compounds 1, 2 and 6 were assayed against both Gram-positive and Gram-negative bacteria. No positive activities were observed.
从兔儿伞（Cacalia ainsliaeflora）的根部分离出一种已知的桉叶烷醇内酯，3β-当归酰氧基-8β,10β-二羟基-6β-甲氧基桉叶烷醇内酯（1）和七种新的桉叶烷倍半萜，3β-当归酰氧基-6β-乙氧基-8β,10β-二羟基桉叶烷醇内酯（2）、3β,6β-二当归酰氧基-10α-羟基-8α-甲氧基桉叶烷醇内酯、6β-当归酰氧基-8β,10β-二羟基-3-氧代-桉叶烷醇内酯、6β,8β,10β-三羟基-3-氧代-桉叶烷醇内酯、3β-当归酰氧基-6β,10β-二羟基-桉叶-7(11),8(9)-二烯-8,12-内酯（6）、3β-当归酰氧基-10β-羟基-6β-甲氧基-桉叶-7(11),8(9)-二烯-8,12-内酯、3β-当归酰氧基-8-氧代-桉叶-6,9-二烯-12-酸乙酯。通过光谱方法阐明了它们的结构。对化合物1、2和6针对革兰氏阳性和革兰氏阴性细菌进行了测定。未观察到阳性活性。
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