来自喀麦隆还阳参（菊科）的倍半萜内酯

Sesquiterpene lactones from Crepis cameroonica (Asteraceae).

作者信息

Ndom J C, Mbafor J T, Wansi J D, Kamdem A W, Meva'a L M, Vardamides J C, Toukam F, Pegyemb D, Ngando T M, Laatsch H, Fomum Z T

机构信息

Faculty of Science, Department of Organic Chemistry, Faculty of Science, University of Douala, Douala, P.O. Box 24157, Cameroon.

出版信息

Nat Prod Res. 2006 May 10;20(5):435-42. doi: 10.1080/14786410500182300.

DOI:10.1080/14786410500182300

PMID:16644541

Abstract

In addition to one known compound, 3beta,8alpha-dihydroxyguaian-4(15),10(14),11(13)-trien-6,12 olide (8-desacylcynaropicrin) (3), two new sesquiterpene lactones have been isolated from the aerial parts of Crepis cameroonica. By means of spectroscopic analysis, the structures and relative configurations of the new compounds were established as 3beta,9beta-dihydroxyguaian-4(15),10(14),11(13)-trien-6,12 olide (1) and 8alpha-hydroxy-4alpha(13),11beta(15)-tetrahydrozaluzanin C (2). The in vitro antimicrobial spectrum of pure compounds and crude extracts are also reported.

摘要

除了一种已知化合物3β,8α - 二羟基愈创木 - 4(15),10(14),11(13) - 三烯 - 6,12 - 内酯（8 - 去酰基洋蓟苦素）（3）外，还从喀麦隆还阳参的地上部分分离出两种新的倍半萜内酯。通过光谱分析，确定了新化合物的结构和相对构型分别为3β,9β - 二羟基愈创木 - 4(15),10(14),11(13) - 三烯 - 6,12 - 内酯（1）和8α - 羟基 - 4α(13),11β(15) - 四氢扎鲁扎宁C（2）。还报道了纯化合物和粗提取物的体外抗菌谱。