Rhoden Ernani Luis, Gobbi Daniel, Rhoden Claudia Ramos, Menti Eduardo, Roehe Adriane Nial, Hartmann Antonio, Morgentaler Abraham
Postgraduate Course of Medical Sciences, Federal University of Rio Grande do Sul, Rua Jaragua 370/302, Bela Viste, 90450-140 Porto Alegre, RS, Brazil.
J Urol. 2003 Nov;170(5):2101-3. doi: 10.1097/01.ju.0000091827.97826.57.
We evaluated the effects of chronic administration of dehydroepiandrosterone (DHEA) on serum total testosterone and DHEA sulfate (DHEAS), prostatic weight and histological features in the rat.
Wistar rats were divided into 2 groups. The first group of 9 rats received saline solution orally once daily during 5 days of the week for 10 months and the second group of 15 received 5 mg/kg daily DHEA in suspension orally in the same pattern.
At the end of the 10-month study period total testosterone levels were higher in the DHEA group compared with controls (2.0 +/- 0.4 vs 0.8 +/- 0.2 mg/dl, p <0.0001) and DHEAS levels were also greater in the treated group compared with placebo (222.1 +/- 41.5 vs 2.0 +/- 0.3 mg/dl, p <0.0001). Weight of the prostate, testis and body did not differ between the groups (p >0.05). No differences between the 2 groups were noted in regard to the degree of hyperplasia, atrophy, a papillary component or the stromal-to-gland ratio (p >0.05).
Oral ingestion of DHEA on a chronic basis in the rat increases serum DHEAS and total testosterone without any evident change in prostate weight or histology.
我们评估了长期给予脱氢表雄酮（DHEA）对大鼠血清总睾酮、硫酸脱氢表雄酮（DHEAS）、前列腺重量及组织学特征的影响。
将Wistar大鼠分为2组。第一组9只大鼠，每周5天每天经口给予盐溶液，持续10个月；第二组15只大鼠，以相同方式经口给予5mg/kg DHEA混悬液。
在10个月的研究期末，DHEA组的总睾酮水平高于对照组（2.0±0.4 vs 0.8±0.2mg/dl，p<0.0001），且治疗组的DHEAS水平也高于安慰剂组（222.1±41.5 vs 2.0±0.3mg/dl，p<0.0001）。两组之间前列腺、睾丸及体重无差异（p>0.05）。两组在增生程度、萎缩程度、乳头状成分或间质与腺体比例方面无差异（p>0.05）。
大鼠长期经口摄入DHEA可增加血清DHEAS和总睾酮水平，而前列腺重量或组织学无明显变化。
