Jarrige J F, Boucher D
Laboratoire de Physiologie Faculté de Médecine, Clermont-Ferrand, France.
J Pineal Res. 1992 Sep;13(2):66-71. doi: 10.1111/j.1600-079x.1992.tb00056.x.
Female rats exposed to long (LD 18:6) or short (LD 6:18) photoperiods from 21 days of age were mated when they reached 55 days of age. On day 2 of gestation animals of each group were either pinealectomized or sham-operated. Lighting regimens were not changed during the course of the study. Male offspring of the four groups of dams were sacrificed on day 70 after birth. Rats that were maintained on long photoperiod had higher testicular testosterone, androstenedione, and dihydrotestosterone content than those raised on a LD 6:18 cycle. Whatever the breeding photoperiod used, maternal pinealectomy induced no modification of reproductive function. Among rats kept in short photoperiod, neonatal pinealectomy (on day 5 after birth) resulted in an enhanced testicular androgen content without any modification of plasma androgen concentration. These results indicate that (1) the previously reported effect of the mother's pineal on pubertal rat testicular function is not present in adulthood and (2) the pineal of the offspring is required to maintain normal testicular androgen content in the adult rat but exerts no influence on circulating androgens.
从21日龄开始暴露于长光照周期（LD 18:6）或短光照周期（LD 6:18）的雌性大鼠，在55日龄时进行交配。在妊娠第2天，每组动物要么接受松果体切除手术，要么接受假手术。在研究过程中光照方案不变。四组母鼠的雄性后代在出生后第70天被处死。与饲养在LD 6:18光照周期的大鼠相比，饲养在长光照周期的大鼠睾丸中的睾酮、雄烯二酮和双氢睾酮含量更高。无论采用何种繁殖光照周期，母体松果体切除均未引起生殖功能的改变。在饲养于短光照周期的大鼠中，新生期松果体切除（出生后第5天）导致睾丸雄激素含量增加，而血浆雄激素浓度未发生任何改变。这些结果表明：（1）先前报道的母体松果体对青春期大鼠睾丸功能的影响在成年期不存在；（2）后代的松果体对于成年大鼠维持正常的睾丸雄激素含量是必需的，但对循环雄激素无影响。
