Morishita Shigeru, Arita Seizaburo
Department of Psychiatry, Kawasaki Medical School, Kurashiki, Okayama, Japan.
Hum Psychopharmacol. 2003 Oct;18(7):565-8. doi: 10.1002/hup.531.
An investigation of the proportion of patients who have experienced mania with antidepressant treatment and their characteristics would seem to be of clinical use.
The purpose of this clinical study was to examine the predictors of induction of mania in depression patients as a result of paroxetine treatment.
A retrospective cohort analysis was carried out among depression patients treated in the Department of Psychiatry, Kawasaki Medical School Hospital, Kurashiki, Japan, in 2000 and 2001. Some 79 patients were identified who were receiving paroxetine to treat depression. A variety of clinical factors including gender, the type of depression, frequency of episodes, family history, age and daily dose were examined as possible predictors of induction of mania by paroxetine.
Seven (8.86%) of the 79 paroxetine-treated patients developed mania. A Cox proportional hazards analysis showed the type of depression and the history of family psychiatric illness to be independent predictive factors of the induction of mania by paroxetine treatment.
The rate of mania induction of paroxetine is not substantially different from that found for conventional antidepressants. The type of depression and the history of family psychiatric illness may be considered as predictors of mania induction in depression patients taking paroxetine treatment.
调查接受抗抑郁治疗的患者中出现躁狂症状的比例及其特征似乎具有临床意义。
本临床研究的目的是检验帕罗西汀治疗导致抑郁症患者诱发躁狂的预测因素。
对2000年和2001年在日本仓敷市川崎医科大学医院精神科接受治疗的抑郁症患者进行回顾性队列分析。确定了约79名正在接受帕罗西汀治疗抑郁症的患者。研究了包括性别、抑郁症类型、发作频率、家族史、年龄和每日剂量在内的各种临床因素，作为帕罗西汀诱发躁狂的可能预测因素。
79名接受帕罗西汀治疗的患者中有7名（8.86%）出现躁狂。Cox比例风险分析表明，抑郁症类型和家族精神病史是帕罗西汀治疗诱发躁狂的独立预测因素。
帕罗西汀诱发躁狂的发生率与传统抗抑郁药没有实质性差异。抑郁症类型和家族精神病史可被视为接受帕罗西汀治疗的抑郁症患者诱发躁狂的预测因素。
