Schrock Richard R, Hoveyda Amir H
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Angew Chem Int Ed Engl. 2003 Oct 6;42(38):4592-633. doi: 10.1002/anie.200300576.
Catalytic olefin metathesis has quickly emerged as one of the most often-used transformations in modern chemical synthesis. One class of catalysts that has led the way to this significant development are the high-oxidation-state alkylidene complexes of molybdenum. In this review key observations that resulted in the discovery and development of molybdenum- and tungsten-based metathesis catalysts are outlined. An account of the utility of molybdenum catalysts in the synthesis of biologically significant molecules is provided as well. Another focus of the review is the use of chiral molybdenum complexes for enantioselective synthesis. These highly efficient catalysts provide unique access to materials of exceptional enantiomeric purity and often without generating solvent waste.
催化烯烃复分解反应已迅速成为现代化学合成中最常用的转化反应之一。引领这一重大发展的一类催化剂是钼的高氧化态亚烷基配合物。在这篇综述中，概述了导致钼基和钨基复分解催化剂发现和发展的关键观察结果。同时也介绍了钼催化剂在生物活性分子合成中的应用。该综述的另一个重点是手性钼配合物在对映选择性合成中的应用。这些高效催化剂为获得对映体纯度极高的材料提供了独特途径，而且通常不会产生溶剂废物。
