Boras Zagorka, Krizanac Simun, Rakusić Neven
Klinika za plućne bolesti Jordanovac, Jordanovac 104, 10000 Zagreb.
Lijec Vjesn. 2003 May-Jun;125(5-6):131-4.
Bronchiolitis obliterans organizing pneumonia (BOOP) is a well-defined clinicopathological entity. The aetiology of BOOP is generally unknown, although it has been associated with specific diseases or various pharmaceutical drugs. The amiodarone is one of them. We report a patient with BOOP secondary to amiodarone therapy, who presented with cough, fever and sputum production, dyspnoea and night sweats lasting for two months. A chest radiograph showed bilateral patchy and interstitial infiltrates. Lymphocyte phenotyping of bronchoalveolar lavage fluid showed decreased ratio of CD4+:CD8+ lymphocytes. Transbronchial lung biopsy established the diagnosis of BOOP. After stopping amiodarone therapy, symptoms disappeared and the chest radiograph remained normal within two months.
闭塞性细支气管炎并机化性肺炎（BOOP）是一种明确的临床病理实体。BOOP的病因通常不明，尽管它与特定疾病或多种药物有关。胺碘酮就是其中之一。我们报告1例胺碘酮治疗继发BOOP的患者，该患者出现咳嗽、发热、咳痰、呼吸困难和盗汗达2个月。胸部X线片显示双侧斑片状和间质性浸润。支气管肺泡灌洗液体淋巴细胞表型分析显示CD4⁺:CD8⁺淋巴细胞比例降低。经支气管肺活检确诊为BOOP。停用胺碘酮治疗后，症状消失，2个月内胸部X线片恢复正常。
