同种免疫性新生儿中性粒细胞减少症是反复自然流产女性接受白细胞免疫治疗的一种潜在副作用。
Alloimmune neonatal neutropenia is a potential side effect of immunization with leukocytes in women with recurrent spontaneous abortions.
作者信息
Bux J, Westphal E, de Sousa F, Mueller-Eckhardt G, Mueller-Eckhardt C
机构信息
Institute for Clinical Immunology and Transfusion Medicine, University of Giessen, FRG.
出版信息
J Reprod Immunol. 1992 Oct;22(3):299-302. doi: 10.1016/0165-0378(92)90050-e.
Alloimmunization of a mother against granulocytes causing alloimmune neonatal neutropenia (ANN) in her newborn was found likely to be attributed to previous intradermal injections of paternal lymphocytes. Immunotherapy with leukocytes which was performed for recurrent spontaneous abortions hence provides the possibility of granulocyte alloimmunization and increases the risk of the occurrence of ANN.
母亲针对粒细胞的同种免疫反应导致其新生儿出现同种免疫性新生儿中性粒细胞减少症（ANN），这很可能归因于之前皮内注射了父亲的淋巴细胞。因此，因复发性自然流产而进行的白细胞免疫疗法提供了粒细胞同种免疫的可能性，并增加了ANN发生的风险。
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