Ito Yasuhiro, Yoshida Hiroshi, Matsuzuka Fumio, Matsuura Nariaki, Nakamura Yasushi, Nakamine Hirokazu, Kakudo Kennichi, Kuma Kanji, Miyauchi Akira
Department of Surgery, Kuma Hospital, Kobe, Japan.
Pathol Res Pract. 2003;199(8):533-8. doi: 10.1078/0344-0338-00458.
Previous studies have demonstrated that the G2-M modulators contribute to the progression of human neoplasms. In this study, we investigated the expression of these modulators, cyclin-dependent kinase 1 (cdc2), and G2 cyclins, cyclin A and cyclin B1, in primary thyroid lymphoma. Cdc2 immunoexpression was observed in 51.0% of the 49 cases examined and was related to grade of malignancy, high Ki-67 labeling index, and aberrant p53 expression. The incidences of immunoexpression of cyclin A and cyclin B1 were 63.3% and 40.9%, respectively, and they were also related to the above three parameters. Furthermore, a correlation was found between the immunoexpression of cdc2 and G2 cyclins. These findings suggest that the cdc2 and G2 cyclins play an important role in the progression of thyroid malignant lymphoma.
先前的研究表明，G2-M调节因子有助于人类肿瘤的进展。在本研究中，我们调查了这些调节因子、细胞周期蛋白依赖性激酶1（cdc2）以及G2期细胞周期蛋白（细胞周期蛋白A和细胞周期蛋白B1）在原发性甲状腺淋巴瘤中的表达情况。在49例检查病例中，51.0%观察到cdc2免疫表达，且其与恶性程度、高Ki-67标记指数及异常p53表达相关。细胞周期蛋白A和细胞周期蛋白B1免疫表达的发生率分别为63.3%和40.9%，它们也与上述三个参数相关。此外，还发现cdc2与G2期细胞周期蛋白的免疫表达之间存在相关性。这些发现表明，cdc2和G2期细胞周期蛋白在甲状腺恶性淋巴瘤的进展中起重要作用。
