Sherman S J, Kovacs B W, Medearis A L, Bear M B, Paul R H
Department of Obstetrics and Gynecology, University of Southern California School of Medicine, Los Angeles.
J Reprod Med. 1992 Sep;37(9):804-8.
Twin pregnancies have higher perinatal morbidity and mortality rates than singleton pregnancies. Researchers have demonstrated that one major benefit of prenatal care in the twin gestation is reduced fetal death rate. This study to determine the relationship of nonstress tests (NSTs) to pregnancy outcome in twin gestations comprised 665 women who delivered at Los Angeles County-University of Southern California Women's Hospital from January 1985 to January 1989. These patients, all of whom had prenatal care (PNC), were subdivided into two groups: (1) PNC and NSTs and (2) PNC and no NSTs. The groups did not differ statistically with regard to gravidity, parity and abortions. NSTs were selectively done on twin gestations complicated by discordancy or other fetal/maternal complications. Ten pregnancies were complicated by fetal demise of one or both twins in patients who received prenatal care without NSTs. Among the NST group there was one fetal demise. Although the NST group had fewer fetal deaths, the reduction was not statistically significant (P = .062). Infant birth weight was identified as a confounder because the NST group had a statistically higher mean birth weight. Definitive proof of the ability of NSTs to reduce the fetal death rate in twin gestations complicated by discordancy or other pregnancy complications awaits a large, prospective, randomized trial.
双胎妊娠的围产期发病率和死亡率高于单胎妊娠。研究人员已经证明,产前护理对双胎妊娠的一个主要益处是降低胎儿死亡率。本研究旨在确定无应激试验(NST)与双胎妊娠结局之间的关系,该研究纳入了1985年1月至1989年1月在洛杉矶县南加州大学妇女医院分娩的665名妇女。所有这些患者都接受了产前护理(PNC),并被分为两组:(1)接受PNC并进行NST的患者;(2)接受PNC但未进行NST的患者。两组在妊娠次数、产次和流产次数方面无统计学差异。NST是对合并双胎生长不一致或其他胎儿/母体并发症的双胎妊娠选择性进行的。在未进行NST的接受产前护理的患者中,有10例妊娠合并一个或两个胎儿死亡。在NST组中有1例胎儿死亡。虽然NST组的胎儿死亡数较少,但降低幅度无统计学意义(P = 0.062)。婴儿出生体重被确定为一个混杂因素,因为NST组的平均出生体重在统计学上较高。关于NST能否降低合并双胎生长不一致或其他妊娠并发症的双胎妊娠胎儿死亡率的确切证据,尚需大规模、前瞻性、随机试验来证实。