Malinowski J J
Polish Academy of Sciences, Institute of Chemical Engineering, ul. Baltycka 5, 44-100 Gliwice, Poland.
Biotechnol Adv. 2001 Nov;19(7):525-38. doi: 10.1016/s0734-9750(01)00080-5.
The two-phase partitioning bioreactor concept appears to have a great potential in enhancing the productivity of many bioprocesses. The proper selection of an organic solvent is the key to successful application of this approach in industrial practice. The integration of fermentation and a primary product separation step has a positive impact on the productivity of many fermentation processes. The controlled substrate delivery from the organic to the aqueous phase opens a new area of application of this strategy to biodegradation of xenobiotics. In this review, the most recent advances in the application of two-liquid phase partitioning bioreactors for product or substrate partitioning are discussed. Modeling and performance optimization studies related to those bioreactor systems are also reviewed.
两相分配生物反应器概念在提高许多生物过程的生产力方面似乎具有巨大潜力。选择合适的有机溶剂是该方法在工业实践中成功应用的关键。发酵与初级产物分离步骤的整合对许多发酵过程的生产力有积极影响。从有机相到水相的受控底物输送为该策略在异生素生物降解中的应用开辟了新领域。在本综述中，讨论了双液相分配生物反应器在产物或底物分配应用方面的最新进展。还综述了与那些生物反应器系统相关的建模和性能优化研究。
