[采用多重扩增法对杜氏肌营养不良症患者肌营养不良蛋白基因缺失情况的分析]
[Analysis of deletions in the dystrophin gene by the multiplex amplification method in patients suffering from Duchenne's muscular dystrophy].
作者信息
Malysheva O V, Poliakov A V, Zaĭtseva S P, Malygina N A, Gorbunova V N, Evgrafov O V, Makarov V G, Krasil'nikov V V, Baranov V S, Vadalian L O
出版信息
Mol Gen Mikrobiol Virusol. 1992 May-Jun(5-6):27-31.
PMID:1454081
Abstract
Multiplex polymerase chain reaction was carried out with the material from 68 patients suffering from Duchenne muscular dystrophy in Moscow and Leningrad clinics. Six pairs of oligoprimers were used. Deletions were detected in the material from 22 patients. A new type of deletion was found. Data on deletion frequencies and spectrum were compared with the results published by other authors.
摘要
对来自莫斯科和列宁格勒诊所的68例杜氏肌营养不良患者的材料进行了多重聚合酶链反应。使用了6对寡核苷酸引物。在22例患者的材料中检测到缺失。发现了一种新型缺失。将缺失频率和谱的数据与其他作者发表的结果进行了比较。
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