Javitt J C, Tielsch J M, Canner J K, Kolb M M, Sommer A, Steinberg E P
Worthen Center for Eye Care Research, Georgetown University Medical Center, Washington, DC.
Ophthalmology. 1992 Oct;99(10):1487-97; discussion 1497-8. doi: 10.1016/s0161-6420(92)31775-0.
The authors studied 57,103 randomly selected Medicare beneficiaries who underwent extracapsular cataract extraction in 1986 or 1987 to determine the possible association between performance of neodymium (Nd):YAG laser capsulotomy and the risk of subsequent retinal break or detachment.
Cases of cataract surgery were identified from Medicare claims submitted in 1986 and 1987 and were followed through the end of 1988. Episodes of cataract surgery, posterior capsulotomy, and retinal complications were ascertained based on procedure and diagnosis codes listed in physician bills and hospital discharge records. Lifetable and Cox's proportional hazards models were used to analyze the risk of retinal detachment or break in patients undergoing and not undergoing capsulotomy during the period of observation.
Of the 57,103 persons identified as having undergone extracapsular cataract extraction in 1986 or 1987, 13,709 subsequently underwent Nd:YAG laser capsulotomy between 1986 and 1988. A total of 337 persons had aphakic or pseudophakic retinal detachments between 1986 and 1988 and an additional 194 underwent repair of a retinal break. Proportional hazards modeling shows a 3.9-fold increase in the risk of retinal break or detachment among those who underwent capsulotomy (95% confidence interval: 2.89 to 5.25). Younger patient age, male sex, and white race also were associated with increased risk of retinal complications after extracapsular cataract extraction.
The authors conclude that there is a statistically significant increase in the risk of retinal detachment or break in those patients who undergo capsulotomy after cataract extraction. Therefore, capsulotomy should be deferred until the patient's impairment caused by capsular opacification warrants the increased risk of retinal complications associated with performance of capsulotomy.
作者研究了1986年或1987年随机选取的57103名接受囊外白内障摘除术的医疗保险受益人,以确定钕(Nd):YAG激光晶状体后囊切开术与随后发生视网膜裂孔或脱离风险之间的可能关联。
从1986年和1987年提交的医疗保险理赔申请中识别出白内障手术病例,并随访至1988年底。根据医生账单和医院出院记录中列出的手术和诊断代码确定白内障手术、晶状体后囊切开术和视网膜并发症的情况。使用生命表和Cox比例风险模型分析观察期内接受和未接受晶状体后囊切开术的患者发生视网膜脱离或裂孔的风险。
在确定为1986年或1987年接受囊外白内障摘除术的57103人中,13709人在1986年至1988年期间随后接受了Nd:YAG激光晶状体后囊切开术。1986年至1988年期间,共有337人发生无晶状体或人工晶状体性视网膜脱离,另有194人接受了视网膜裂孔修复。比例风险模型显示,接受晶状体后囊切开术的患者发生视网膜裂孔或脱离的风险增加了3.9倍(95%置信区间:2.89至5.25)。患者年龄较小、男性和白人种族也与囊外白内障摘除术后视网膜并发症风险增加有关。
作者得出结论,白内障摘除术后接受晶状体后囊切开术的患者发生视网膜脱离或裂孔的风险在统计学上显著增加。因此,应推迟进行晶状体后囊切开术,直到因晶状体混浊导致的患者功能损害值得承担与晶状体后囊切开术相关的视网膜并发症增加的风险。