Weatherhead R G
Division of Oculoplastic Surgery, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
Ophthalmology. 1992 Oct;99(10):1575-81. doi: 10.1016/s0161-6420(92)31764-6.
A unique series of 13 cases of ductal cysts of the accessory lacrimal glands of Wolfring is presented. Once appreciated, they are an easily recognized clinical entity.
The 13 cases were verified histologically as arising from ductal epithelium. Biochemical analyses for serum and cyst fluid concentrations of IgA, IgG, and IgM were performed on three of the cases. Histologic staining of the cyst wall using monoclonal antibodies to immunoglobulins was performed on one case.
All patients had evidence of extensive trachomatous scarring. High levels of IgA were found in the cyst fluid, consistent with an active secretory mechanism. Monoclonal antibody staining suggested a significant role for paraductal IgA-secreting plasma cells.
The formation of a ductal cyst appears to require two successive, inter-related events. The first is an ongoing active secretory process, and the second is an occlusion of the duct. The sequential occurrence of these two events is forwarded as the explanation of dacryops formation. Excision using a conjunctival approach is recommended. A small strip of tarsal border should be removed with the cyst to prevent cyst rupture. The excretory ducts of the Wolfring glands exit through this area.
本文报道了一系列独特的13例沃尔夫林副泪腺导管囊肿病例。一旦被认识到,它们是一种易于识别的临床实体。
13例经组织学证实起源于导管上皮。对其中3例进行了血清和囊液中IgA、IgG和IgM浓度的生化分析。对1例囊肿壁进行了用免疫球蛋白单克隆抗体的组织学染色。
所有患者均有广泛沙眼瘢痕的证据。囊液中发现高水平的IgA,与活跃的分泌机制一致。单克隆抗体染色提示导管周围分泌IgA的浆细胞起重要作用。
导管囊肿的形成似乎需要两个连续且相互关联的事件。第一个是持续的活跃分泌过程,第二个是导管阻塞。这两个事件的相继发生被认为是泪腺囊肿形成的解释。建议采用结膜入路切除。切除囊肿时应切除一小条睑缘,以防止囊肿破裂。沃尔夫林腺的排泄管从此区域穿出。