外源基因在多形汉逊酵母中的高水平表达。
High-level expression of foreign genes in Hansenula polymorpha.
作者信息
Gellissen G, Janowicz Z A, Weydemann U, Melber K, Strasser A W, Hollenberg C P
机构信息
Rhein Biotech GmbH, Düsseldorf, Germany.
出版信息
Biotechnol Adv. 1992;10(2):179-89. doi: 10.1016/0734-9750(92)90002-q.
The methylotrophic yeast Hansenula polymorpha belongs to a limited number of non-Saccharomyces yeast species used as hosts for heterologous gene expression. It has successfully been applied for the production of hormones, antigens and enzymes. The system excells by mitotically stable recombinant strains, high productivity and faithful processing of the produced polypeptides. The favourable characteristics of this microorganism for protein production at an industrial scale are described in the following article focusing on some recent representative examples.
多形汉逊酵母这种甲基营养型酵母属于少数用作异源基因表达宿主的非酿酒酵母物种。它已成功应用于激素、抗原和酶的生产。该系统的优点是重组菌株有丝分裂稳定、生产力高以及所产生的多肽加工准确。本文聚焦于一些近期的代表性实例，阐述了这种微生物在工业规模蛋白质生产方面的有利特性。
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