[用哌仑西平阻断胆碱能系统后1型糖尿病患者生长激素（GH）对生长激素释放激素（GHRH）反应的抑制作用]
[Inhibition of growth hormone (GH) response to GHRH in diabetes mellitus type 1 after blockade of the cholinergic system with pirenzepine].
作者信息
Krassowski J, Rogala H, Jeske W, Zgliczyński S
机构信息
Kliniki Endokrynologii CMKP w Warszawie.
出版信息
Pol Arch Med Wewn. 1992 Jul;88(1):25-9.
The effect of pirenzepine, a peripheric cholinergic antagonist, on GHRH-induced GH secretion was studied in 10 type I diabetic subjects and 8 healthy controls. GH response was significantly greater in diabetics than in the healthy controls (p < 0.02) with peak values of 59.6 and 15.9 ng/ml, respectively. Pirenzepine 20 mg in given 15 min before GHRH inhibited GH response in both groups. In diabetics GH response calculated as area under curve (AUC) was inhibited from 3666 to 260 ng/ml. min (p < 0.001) and in the controls from 831 to 255 ng/ml. min (p < 0.05). The great efficacy of pirenzepine in inhibiting GH hypersecretion in type I diabetes may find a clinical application in future.
在10名I型糖尿病患者和8名健康对照者中研究了外周胆碱能拮抗剂哌仑西平对生长激素释放激素（GHRH）诱导的生长激素（GH）分泌的影响。糖尿病患者的GH反应明显大于健康对照者（p<0.02），峰值分别为59.6和15.9 ng/ml。在给予GHRH前15分钟给予20 mg哌仑西平可抑制两组的GH反应。在糖尿病患者中，以曲线下面积（AUC）计算的GH反应从3666降至260 ng/ml·min（p<0.001），在对照组中从831降至255 ng/ml·min（p<0.05）。哌仑西平在抑制I型糖尿病患者GH分泌过多方面的高效性可能在未来找到临床应用。
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