Babiuk L A, Potter A A
Veterinary Infectious Disease Organization, Saskatoon, Saskatchewan, Canada.
Biotechnol Adv. 1994;12(3):489-523. doi: 10.1016/0734-9750(94)90021-3.
Vaccination of animals for the prevention of infectious diseases has been practised for a number of years with little change in product composition. Recent advances in molecular biology, pathogenesis and immunology have laid the groundwork for the development of a new generation of veterinary vaccines based on pure subunits as well as live vectored bacteria and viruses. Along with novel methods of antigen preparation, the use of new adjuvants and delivery systems will permit targeting of the appropriate immune response as well as offering flexibility in terms of vaccination protocols. These new technologies are also being applied to the development of vaccines to enhance animal productivity and to control reproduction.
通过接种疫苗预防动物传染病的做法已经实施多年，产品成分变化不大。分子生物学、发病机制和免疫学的最新进展为新一代兽用疫苗的开发奠定了基础，这些疫苗基于纯亚单位以及活载体细菌和病毒。随着新型抗原制备方法的出现，新型佐剂和递送系统的使用将能够靶向适当的免疫反应，并在疫苗接种方案方面提供灵活性。这些新技术也正应用于开发提高动物生产力和控制繁殖的疫苗。
