Antonello M, Polico R, Busetto M, Pizzi G
Divisione di Radioterapia Oncologica, O.C. Umberto I, Mestre, Venezia.
Radiol Med. 1992 Oct;84(4):440-3.
From January 1984 through December 1990, 311 patients affected with breast cancer were treated with quadrantectomy plus lymphadenectomy and radiation therapy (QUART) at the Umberto I Hospital in Mestre, Italy. The patients with positive nodes (N+) were treated with adjuvant chemotherapy (CMF) or hormonotherapy (Tamoxifen) according to pausal status. Most patients were in the 5th, 6th and 7th decades of life; 60.5% of them were over 50. Staging was always performed according to TNM classification (UICC criteria) and demonstrated mostly stage-I lesions (66.9%). Overall and disease-free (NED) survival rates were 95%; mean survival rates were 7.47 (+/- 0.138) and 7.22 (+/- 0.164) years, respectively. Ten patients died (5 from breast cancer); 6 local relapses were observed and 8 metastases. Metastases were seen mostly in patients with breast cancer in the internal quadrants (QI) N0, with no statistically significant differences relative to the other groups. This is probably due to the existence of an axillary pN0 and parasternal N+ group of patients, who receive insufficient treatment.
1984年1月至1990年12月期间，意大利梅斯特雷的翁贝托一世医院对311例乳腺癌患者进行了象限切除术加淋巴结清扫术及放射治疗（QUART）。淋巴结阳性（N+）的患者根据绝经状态接受辅助化疗（CMF）或激素治疗（他莫昔芬）。大多数患者年龄在50多岁、60多岁和70多岁；其中60.5%的患者年龄超过50岁。分期始终按照TNM分类（国际抗癌联盟标准）进行，大多数为I期病变（66.9%）。总生存率和无病（NED）生存率均为95%；平均生存率分别为7.47（±0.138）年和7.22（±0.164）年。10例患者死亡（5例死于乳腺癌）；观察到6例局部复发和8例转移。转移主要见于内象限（QI）N0的乳腺癌患者，与其他组相比无统计学显著差异。这可能是由于存在一组腋窝pN0和胸骨旁N+的患者，他们接受的治疗不足。
