Ruiz i Altaba Ariel, Nguyên Vân, Palma Verónica
The Skirball Institute, New York University School of Medicine, New York, New York 10016, USA.
Curr Opin Genet Dev. 2003 Oct;13(5):513-21. doi: 10.1016/j.gde.2003.08.005.
The Sonic hedgehog (Shh) pathway plays an important role in the development of many tissues and organs. The secreted ligand Shh has been shown to act as a mitogen, morphogen and survival factor in different contexts whereas the three Gli transcription factors act as Shh mediators in a context-dependent combinatorial fashion. The common wisdom has been that Gli protein function is subject to Shh signaling. One can ask how Gli proteins act and what the nature of Shh signaling during CNS dorsal-ventral patterning is. Is it possible that Hedgehog signals are only one of several ways to regulate Gli activity? Moreover, in light of the partial rescue of the neural tube phenotype of Shh or Smoothened mutant embryos in Shh(-/-);Gli3(-/-), Smoothened(-/-);Gli3(-/-), and Shh(-/-);Rab23(-/-) double null embryos, one can consider the roles that the Shh-Gli pathway may have taken to orchestrate congruent prepattern and growth, and the importance of creating the correct number of precursors in patterning mechanisms.
音猬因子（Shh）信号通路在许多组织和器官的发育中起着重要作用。分泌型配体Shh已被证明在不同情况下可作为促有丝分裂原、形态发生素和存活因子，而三种Gli转录因子则以上下文依赖的组合方式作为Shh信号的介质。普遍的观点是Gli蛋白的功能受Shh信号传导的影响。人们可能会问，Gli蛋白是如何发挥作用的，以及在中枢神经系统背腹模式形成过程中Shh信号传导的本质是什么。刺猬信号是否只是调节Gli活性的几种方式之一？此外，鉴于在Shh(-/-);Gli3(-/-)、Smoothened(-/-);Gli3(-/-)和Shh(-/-);Rab23(-/-)双缺失胚胎中，Shh或Smoothened突变胚胎的神经管表型得到了部分挽救，人们可以思考Shh-Gli信号通路在协调一致的预模式和生长过程中可能发挥的作用，以及在模式形成机制中产生正确数量的前体细胞的重要性。
