犬轴向骨骼骨肉瘤。对116例病例的回顾性研究（1986年至1989年）。

Canine axial skeletal osteosarcoma. A retrospective study of 116 cases (1986 to 1989).

作者信息

Heyman S J, Diefenderfer D L, Goldschmidt M H, Newton C D

机构信息

Department of Clinical Studies, Veterinary Hospital of the University of Pennsylvania, Philadelphia.

出版信息

Vet Surg. 1992 Jul-Aug;21(4):304-10. doi: 10.1111/j.1532-950x.1992.tb00069.x.

DOI:10.1111/j.1532-950x.1992.tb00069.x

PMID:1455640

Abstract

Axial skeletal osteosarcomas were evaluated retrospectively in 116 dogs. Thirty-one tumors occurred in the mandible, 26 in the maxilla, 17 in the spine, 14 in the cranium, 12 in the ribs, 10 in the nasal cavity and paranasal sinuses, and 6 in the pelvis. Medium-sized and large dogs were most commonly affected. Females outnumbered males 2.1:1, but this varied with tumor location. The mean age was 8.7 years. Osteosarcomas of the rib occurred in significantly younger dogs (mean age, 5.4 years) than osteosarcomas at any other axial skeletal site. Pulmonary metastasis was diagnosed radiographically in 11.1% of the dogs. The median survival for dogs treated surgically was 22 weeks, the 1-year survival was 26.3%, and the 2-year survival was 18.4%. The tumor recurrence rate was 66.7%. Most dogs (79.6%) died or were euthanatized for problems associated with the primary tumor.

摘要

对116只犬的轴向骨骼骨肉瘤进行了回顾性评估。31个肿瘤发生在下颌骨，26个在上颌骨，17个在脊柱，14个在颅骨，12个在肋骨，10个在鼻腔和鼻窦，6个在骨盆。中型和大型犬最常受影响。雌性与雄性的比例为2.1:1，但这因肿瘤位置而异。平均年龄为8.7岁。肋骨骨肉瘤发生的犬明显比其他任何轴向骨骼部位的骨肉瘤犬年轻（平均年龄5.4岁）。11.1%的犬经放射学诊断有肺转移。接受手术治疗的犬的中位生存期为22周，1年生存率为26.3%，2年生存率为18.4%。肿瘤复发率为66.7%。大多数犬（79.6%）因与原发性肿瘤相关的问题死亡或被安乐死。