感染人类免疫缺陷病毒并接受美沙酮治疗的患者出现QT间期延长和尖端扭转型室速。

QT prolongation and Torsades de Pointes in patients infected with human immunodeficiency virus and treated with methadone.

作者信息

Gil Merce, Sala Montserrat, Anguera Ignasi, Chapinal Olga, Cervantes Manuel, Guma Joan R, Segura Ferran

机构信息

Internal Medicine Department, Infectious Diseases Unit, Corporació Sanitària Parc Taulí-Hospital de Sabadell, Barcelona, Spain.

出版信息

Am J Cardiol. 2003 Oct 15;92(8):995-7. doi: 10.1016/s0002-9149(03)00906-8.

DOI:10.1016/s0002-9149(03)00906-8

PMID:14556883

Abstract

Four patients infected with human immunodeficiency virus receiving antiretroviral treatment and high doses of methadone (>200 mg/day) presented with several syncopal episodes. A significant prolongation of the QTc interval was detected in all of them, and in 3 patients, > or =1 episode of Torsades de Pointes was recorded. The sequence of events in these cases suggests that high doses of methadone caused QT prolongation and provided the substrate for syncope and Torsades de Pointes.

摘要

4例接受抗逆转录病毒治疗且服用高剂量美沙酮（>200毫克/天）的人类免疫缺陷病毒感染者出现了多次晕厥发作。所有患者均检测到QTc间期显著延长，3例患者记录到≥1次尖端扭转型室速发作。这些病例中的事件顺序表明，高剂量美沙酮导致QT延长，并为晕厥和尖端扭转型室速提供了基础。