用表达源自约氏疟原虫环子孢子蛋白的CD8 + T细胞表位的重组冷适应流感病毒和改良痘苗安卡拉病毒进行初免-加强免疫诱导抗疟疾保护性免疫。
Induction of protective immunity against malaria by priming-boosting immunization with recombinant cold-adapted influenza and modified vaccinia Ankara viruses expressing a CD8+-T-cell epitope derived from the circumsporozoite protein of Plasmodium yoelii.
作者信息
González-Aseguinolaza Gloria, Nakaya Yurie, Molano Alberto, Dy Edward, Esteban Mariano, Rodríguez Dolores, Rodríguez Juan Ramón, Palese Peter, García-Sastre Adolfo, Nussenzweig Ruth S
机构信息
Department of Medical & Molecular Parasitology, NYU School of Medicine. Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA.
出版信息
J Virol. 2003 Nov;77(21):11859-66. doi: 10.1128/jvi.77.21.11859-11866.2003.
Abstract
We immunized mice with an attenuated (cold-adapted) influenza virus followed by an attenuated vaccinia virus (modified vaccinia virus Ankara), both expressing a CD8(+)-T-cell epitope derived from malaria sporozoites. This vaccination regimen elicited high levels of protection against malaria. This is the first time that the vaccine efficacy of a recombinant cold-adapted influenza virus vector expressing a foreign antigen has been evaluated.
摘要
我们先用减毒（冷适应）流感病毒免疫小鼠，随后用减毒痘苗病毒（安卡拉改良痘苗病毒）免疫，这两种病毒均表达源自疟原虫的CD8(+) -T细胞表位。这种疫苗接种方案引发了高水平的抗疟疾保护作用。这是首次评估表达外源抗原的重组冷适应流感病毒载体的疫苗效力。
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