Hiatt Bradley, DesJardin Lucy, Carter Thomas, Gingrich Roger, Thompson Curt, de Magalhaes-Silverman Margarida
Division of Hematology, Oncology, Blood and Marrow Transplantation, Department of Internal Medicine, College of Medicine, and University of Iowa, Iowa City, USA.
Clin Infect Dis. 2003 Nov 1;37(9):e129-31. doi: 10.1086/378891. Epub 2003 Oct 6.
West Nile virus (WNV) can cause severe, potentially fatal neurological illnesses, which include encephalitis, meningitis, Guillain-Barré syndrome, and anterior myelitis. Because of the short viremic phase, WNV infection is most commonly diagnosed by detection of immunoglobulin M antibody to WNV in serum or cerebrospinal fluid (CSF). We describe a patient with T cell lymphoma who had undergone a T cell-depleted bone marrow transplantation and developed fatal WNV infection. The results of serological tests of blood samples and of CSF tests were negative. Diagnosis was made postmortem by a positive result of reverse-transcriptase polymerase chain reaction (ABI 7700; TaqMan) for WNV in stored CSF and serum samples.
西尼罗河病毒（WNV）可引发严重的、可能致命的神经系统疾病，其中包括脑炎、脑膜炎、格林-巴利综合征和急性脊髓炎。由于病毒血症期较短，WNV感染最常通过检测血清或脑脊液（CSF）中针对WNV的免疫球蛋白M抗体来诊断。我们描述了一名患有T细胞淋巴瘤的患者，该患者接受了T细胞去除的骨髓移植，并发生了致命的WNV感染。血液样本和脑脊液检测的血清学结果均为阴性。死后通过对储存的脑脊液和血清样本进行西尼罗河病毒逆转录酶聚合酶链反应（ABI 7700；TaqMan）检测呈阳性而确诊。
