Kolmakova E V, Shulutko B I, Shishkin A N
Lik Sprava. 1992 Jun(6):91-4.
The nephrotic syndrome is characterized by proteinuria, hypoalbuminemia and hypercholesterolemia. Hypercholesterolemia is in some cases a risk factor for atherosclerosis in this group of patients. The lipid plasma spectrum was studied in 45 patients with the nephrotic syndrome. Most pronounced changes of the lipid composition of the plasma were revealed in patients with systemic lupus erythematosus and a special form of mesangio-proliferative glomerulonephritis which is characterized by a torpid course and rapid development of chronic renal failure. Plasma atherogenicity was calculated according to the index of plasma atherogenicity. A high atherogenicity index was revealed in patients with an association of the nephrotic syndrome and arterial hypertension. Plasma atherogenicity is determined mainly by the level of high-density-lipoprotein cholesterol.
肾病综合征的特征为蛋白尿、低白蛋白血症和高胆固醇血症。在这类患者中，高胆固醇血症在某些情况下是动脉粥样硬化的危险因素。对45例肾病综合征患者的血脂谱进行了研究。在系统性红斑狼疮患者以及一种特殊形式的系膜增生性肾小球肾炎患者中，血浆脂质成分的变化最为明显，这种特殊形式的系膜增生性肾小球肾炎的特点是病程隐匿且慢性肾衰竭发展迅速。根据血浆致动脉粥样硬化指数计算血浆致动脉粥样硬化性。在肾病综合征与动脉高血压相关的患者中发现了高致动脉粥样硬化指数。血浆致动脉粥样硬化性主要由高密度脂蛋白胆固醇水平决定。
