双功能有机催化剂催化丙二酸酯与硝基烯烃的对映选择性迈克尔反应。
Enantioselective Michael reaction of malonates to nitroolefins catalyzed by bifunctional organocatalysts.
作者信息
Okino Tomotaka, Hoashi Yasutaka, Takemoto Yoshiji
机构信息
Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan.
出版信息
J Am Chem Soc. 2003 Oct 22;125(42):12672-3. doi: 10.1021/ja036972z.
PMID:14558791
Abstract
Michael reaction of malonates to nitroolefins with chiral bifunctional organocatalysts, bearing both a thiourea and tertiary amino group, afforded Michael adducts with high yields and enantioselectivities (up to 95%, up to 93% ee).
摘要
带有硫脲和叔氨基的手性双功能有机催化剂催化丙二酸酯与硝基烯烃的迈克尔反应，可高产率、高对映选择性地得到迈克尔加成物（产率高达95%，对映体过量值高达93%）。
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