一种新型醋酸铜-双（恶唑啉）催化的对映选择性亨利反应。
A new copper acetate-bis(oxazoline)-catalyzed, enantioselective Henry reaction.
作者信息
Evans David A, Seidel Daniel, Rueping Magnus, Lam Hon Wai, Shaw Jared T, Downey C Wade
机构信息
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
出版信息
J Am Chem Soc. 2003 Oct 22;125(42):12692-3. doi: 10.1021/ja0373871.
A highly enantioselective, nitroaldol reaction catalyzed by a chiral Cu(II) bis(oxazoline) complex has been developed. The reaction scope includes both aromatic and aliphatic aldehydes (15 examples) affording products in good yields and enantioselectivities (87-94% ee). An X-ray structure of the catalyst has been provided along with a rationalization of the sense of asymmetric induction.
已开发出一种由手性铜（II）双恶唑啉配合物催化的高度对映选择性硝基羟醛反应。反应范围包括芳香族和脂肪族醛（15个例子），能以良好的产率和对映选择性（对映体过量值为87 - 94%）得到产物。已给出催化剂的X射线结构以及不对称诱导方向的合理解释。
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