Diao Haiyan, Chen Yujia, Liu Feng
Department of Chemistry, Fudan University, Shanghai 200438, China.
School of Chemistry and Chemical Engineering, Lanzhou Jiaotong University, Lanzhou 730070, China.
Molecules. 2025 Jan 10;30(2):250. doi: 10.3390/molecules30020250.
This review highlights significant advances in iron-catalyzed cross-dehydrogenative coupling (CDC), a method pivotal for forming carbon-carbon (C-C) bonds directly from C-H bonds. This technique uses iron-a naturally abundant, inexpensive, and environmentally benign transition metal-as a catalyst to facilitate the coupling of two unfunctionalized C-H bonds. This method stands out for avoiding pre-functionalized substrates, reducing both waste and cost in organic synthesis. The discussion includes a variety of CDC methodologies involving combinations of C(sp)-H with C(sp)-H, C(sp)-H with C(sp)-H, and C(sp)-H with C(sp)-H bonds. These methods have been successfully applied in synthesizing complex molecules and pharmaceuticals, highlighting the versatility and efficiency of iron catalysis.
本综述重点介绍了铁催化交叉脱氢偶联反应（CDC）的重大进展，该方法是直接由碳氢键形成碳-碳（C-C）键的关键方法。该技术使用铁——一种天然丰富、价格低廉且环境友好的过渡金属——作为催化剂，以促进两个未官能团化的碳氢键的偶联。该方法的突出之处在于避免了预官能团化的底物，减少了有机合成中的废物和成本。讨论内容包括多种CDC方法，涉及C(sp)-H与C(sp)-H、C(sp)-H与C(sp)-H以及C(sp)-H与C(sp)-H键的组合。这些方法已成功应用于合成复杂分子和药物，突出了铁催化的多功能性和效率。
