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[保留部分前列腺的根治性膀胱切除术治疗浸润性膀胱癌]

[Radical cystectomy with sparing partial prostate for invasive bladder cancer].

作者信息

Zhou Fang-Jian, Qin Zi-Ke, Han Hui, Liu Zhuo-Wei, Wu Zhi-Gang

机构信息

Department of Urology, Cancer Center, Sun Yat-Sen University, Guangzhou, Guangdong, 510060, PR China.

出版信息

Ai Zheng. 2003 Oct;22(10):1066-9.

Abstract

BACKGROUND & OBJECTIVE: Classical radical cystectomy for invasive bladder cancer removes the urinary bladder and prostate completely and was associated with high incidence of post-operative impotence and urinary incontinence. It is uncertain whether prostate excision has any effects on the prognosis of patients undergone cystectomy if the prostate is not involved by the tumor. Sparing the prostate in radical cystectomy might improve potency and urinary control. This paper was to report our experience of sparing partial prostate in radical cystectomy for ten male patients.

METHOD

Transurethral resection of the prostate and radical cystectomy with sparing partial prostatic capsula were carried out in 10 male patients with invasive bladder transitional cell carcinoma. Intestinal neobladder, anastomosed with the residual capsula, were used for reconstruction of the lower urinary tract. Clinical outcome of these patients including tumor control,urinary continence, and sexual status was evaluated.

RESULTS

Mean follow-up was 9 months (range 3-12 months). Postoperative pathological stage was T2N0M0 in all patients. Nine patients survived free of disease. One patient who had recurrence of poorly differentiated transitional cell carcinoma developed metastasis in bone and lymph nodes two months after cystectomy. All patients voided smoothly. Nine patients were continent day and night. One patient had mild incontinence. Of 8 patients with previously sexual function, 6 maintained potency.

CONCLUSION

Satisfactory urinary control and sexual potency could be achieved in radical cystectomy with sparing partial prostate. Further study is needed about the long-term effects of sparing prostate in cystectomy on tumor control.

摘要

背景与目的

经典的浸润性膀胱癌根治性膀胱切除术会完全切除膀胱和前列腺,术后阳痿和尿失禁的发生率较高。如果前列腺未被肿瘤累及,前列腺切除对接受膀胱切除术患者的预后是否有影响尚不确定。在根治性膀胱切除术中保留前列腺可能会改善性功能和控尿能力。本文报告我们对10例男性患者在根治性膀胱切除术中保留部分前列腺的经验。

方法

对10例浸润性膀胱移行细胞癌男性患者行经尿道前列腺切除术及保留部分前列腺包膜的根治性膀胱切除术。采用与残余包膜吻合的回肠新膀胱重建下尿路。评估这些患者的临床结局,包括肿瘤控制、尿失禁和性功能状态。

结果

平均随访9个月(范围3 - 12个月)。所有患者术后病理分期均为T2N0M0。9例患者无病生存。1例低分化移行细胞癌复发患者在膀胱切除术后2个月出现骨和淋巴结转移。所有患者排尿通畅。9例患者日夜控尿良好。1例患者有轻度尿失禁。在8例术前有性功能的患者中,6例维持了性功能。

结论

保留部分前列腺的根治性膀胱切除术可取得满意的控尿和性功能效果。关于膀胱切除术中保留前列腺对肿瘤控制的长期影响还需要进一步研究。

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