被动免疫作为预防措施：何时何地会起作用？

Passive immunization as prophylaxis: when and where will this work?

作者信息

Dunman Paul M, Nesin Mirjana

机构信息

Bacterial Vaccines, Wyeth, 401 N. Middletown Road, Pearl River, NY 10965, USA.

出版信息

Curr Opin Pharmacol. 2003 Oct;3(5):486-96. doi: 10.1016/j.coph.2003.05.005.

DOI:10.1016/j.coph.2003.05.005

PMID:14559093

Abstract

The strict definition of passive immunoprophylaxis includes the administration of exogenously produced antibodies (polyclonal and monoclonal) to prevent infections in exposed individuals, inactivate bacterial toxins or "correct" hypogammaglobulinemia in immunocompromised hosts. This definition can be broadened to include modulators of the immune system. Despite advances in chemotherapy and vaccine development, suitable treatment is not currently available for many pathogens. As a result, passive immunization is an appropriate therapeutic option for many organisms.

摘要

被动免疫预防的严格定义包括给予外源性产生的抗体（多克隆抗体和单克隆抗体），以预防暴露个体感染、使细菌毒素失活或“纠正”免疫功能低下宿主的低丙种球蛋白血症。这个定义可以扩大到包括免疫系统调节剂。尽管化疗和疫苗开发取得了进展，但目前许多病原体仍没有合适的治疗方法。因此，被动免疫是许多病原体的一种合适治疗选择。