Lehrnbecher T
Pädiatrische Hämatologie und Onkologie, Universität Frankfurt, Germany.
Klin Padiatr. 2001 Sep;213 Suppl 1:A103-5. doi: 10.1055/s-2001-17506.
Treatment with intensive myelosuppressive therapy results in decreased levels of immunoglobulins. Whereas pediatric cancer patients undergoing chemotherapy do not benefit from the routine administration of intravenous immunoglobulins, prophylactic intravenous immunoglobulins given after bone marrow transplantation or after peripheral stem cell transplantation reduce infectious complications. Still, prospective clinical trials are needed to define specific treatment groups who can benefit from immunoglobulin support. In addition, randomized studies are required to evaluate the proper dosage and duration of therapy. Passive immunization of children potentially incubated with varicella or measles is generally recommended.
强化骨髓抑制疗法会导致免疫球蛋白水平降低。接受化疗的儿科癌症患者无法从静脉注射免疫球蛋白的常规给药中获益，而在骨髓移植或外周干细胞移植后给予预防性静脉注射免疫球蛋白可减少感染并发症。尽管如此，仍需要进行前瞻性临床试验来确定能从免疫球蛋白支持中获益的特定治疗组。此外，还需要进行随机研究来评估治疗的适当剂量和持续时间。一般建议对可能感染水痘或麻疹的儿童进行被动免疫。
