Berks Ben C, Palmer Tracy, Sargent Frank
Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.
Adv Microb Physiol. 2003;47:187-254. doi: 10.1016/s0065-2911(03)47004-5.
The Tat (twin arginine translocation) protein transport system functions to export folded protein substrates across the bacterial cytoplasmic membrane and to insert certain integral membrane proteins into that membrane. It is entirely distinct from the Sec pathway. Here, we describe our current knowledge of the molecular features of the Tat transport system. In addition, we discuss the roles that the Tat pathway plays in the bacterial cell, paying particular attention to the involvement of the Tat pathway in the biogenesis of cofactor-containing proteins, in cell wall biosynthesis and in bacterial pathogenicity.
Tat（双精氨酸转运）蛋白转运系统的功能是将折叠好的蛋白质底物输出穿过细菌细胞质膜，并将某些整合膜蛋白插入该膜中。它与Sec途径完全不同。在此，我们描述了目前对Tat转运系统分子特征的了解。此外，我们讨论了Tat途径在细菌细胞中所起的作用，特别关注Tat途径在含辅因子蛋白的生物合成、细胞壁生物合成和细菌致病性中的作用。
