Nichols John C, Amato Josh E, Chung Sophia M
Department of Ophthalmology, University of Arizona, College of Medicine, Tucson, Arizona, USA.
J Pediatr Ophthalmol Strabismus. 2003 Sep-Oct;40(5):293-6. doi: 10.3928/0191-3913-20030901-11.
To assess the prevalence and location of Lisch nodules among patients with neurofibromatosis type 1.
This was a prospective observational case series in which 369 consecutive patients from a neurofibromatosis clinic participated. Predetermined inclusion and exclusion criteria were applied to these participants. The presence of Lisch nodules was determined by one of the authors (SMC). The percentage of patients with neurofibromatosis type 1 with Lisch nodules was calculated. Lisch nodules were characterized as being distributed superiorly, inferiorly, or equally in each eye. The percentage of eyes in each group was ascertained.
Among patients of all ages with neurofibromatosis type 1, 63.2% had Lisch nodules, whereas 92% of postpubertal patients had Lisch nodules. Among eyes with Lisch nodules, 80% had an inferior distribution.
This study corroborated previously reported data regarding the prevalence of Lisch nodules in patients with neurofibromatosis type 1 and found that Lisch nodules were predominantly located inferiorly on the iris. The authors propose that exposure to sunlight may be the mechanism for this distribution of hamartomatous nodules.
评估1型神经纤维瘤病患者中Lisch结节的患病率及位置。
这是一项前瞻性观察性病例系列研究，来自神经纤维瘤病诊所的369例连续患者参与其中。对这些参与者应用了预定的纳入和排除标准。Lisch结节的存在由作者之一（SMC）确定。计算1型神经纤维瘤病患者中存在Lisch结节的百分比。Lisch结节的特征为在每只眼中分布于上方、下方或均等分布。确定每组眼中的百分比。
在所有年龄段的1型神经纤维瘤病患者中，63.2%有Lisch结节，而青春期后患者中有92%有Lisch结节。在有Lisch结节的眼中，80%分布于下方。
本研究证实了先前报道的关于1型神经纤维瘤病患者中Lisch结节患病率的数据，并发现Lisch结节主要位于虹膜下方。作者提出，暴露于阳光下可能是错构瘤结节这种分布的机制。
