人类动脉粥样硬化动脉壁发育阶段中受体-Ck的功能蛋白质组学
Functional proteomics of receptor-Ck in the developmental stages of human atherosclerotic arterial wall.
作者信息
Kaul D, Kaur R, Baba I, Singh D
机构信息
Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh.
出版信息
Indian Heart J. 2003 May-Jun;55(3):252-5.
BACKGROUND
The study was undertaken to understand the relationship between the functional proteomics of receptor-Ck and developmental stages of human atherosclerotic aortic wall.
METHODS AND RESULTS
Gene expression study of 25 aortas was undertaken and the results revealed a gradual increase in receptor-Ck gene expression paralleled by the regulatory response of its effector genes coding for sterol response element-binding protein, p27, cyclin D, interleukin-6 and CD40 from a normal to atherosclerotic arterial wall (viz. fatty streak and fibrofatty/fibrous plaque).
CONCLUSIONS
Based upon this and our earlier studies, we propose that cholesterol-specific receptor-Ck-dependent gene regulation may be of crucial importance in atherogenesis.
背景
开展该研究以了解受体Ck的功能蛋白质组学与人类动脉粥样硬化主动脉壁发育阶段之间的关系。
方法与结果
对25个主动脉进行了基因表达研究，结果显示受体Ck基因表达逐渐增加，同时其效应基因（编码固醇调节元件结合蛋白、p27、细胞周期蛋白D、白细胞介素-6和CD40）的调节反应也从正常动脉壁到动脉粥样硬化壁（即脂纹和纤维脂肪/纤维斑块）呈平行变化。
结论
基于此以及我们早期的研究，我们提出胆固醇特异性受体Ck依赖性基因调控可能在动脉粥样硬化形成中至关重要。
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