Kamada Y, Sekito T, Ohsumi Y
Department of Cell Biology, National Institute for Basic Biology, 444-8585, Okazaki, Japan.
Curr Top Microbiol Immunol. 2004;279:73-84. doi: 10.1007/978-3-642-18930-2_5.
TOR plays a key role in cell growth and cell-cycle progression, but in addition recent studies have shown that TOR is also involved in the regulation of a number of molecular processes associated with nutrient deprivation, such as autophagy. In budding yeast, TOR negatively regulates activation of Apg1 protein kinase, which is essential for the induction of autophagy. This review describes recent research in this field and the mechanism by which TOR mediates induction of autophagy.
TOR在细胞生长和细胞周期进程中发挥关键作用，但最近的研究还表明，TOR也参与了许多与营养剥夺相关的分子过程的调控，如自噬。在芽殖酵母中，TOR负向调节Apg1蛋白激酶的激活，而Apg1蛋白激酶对自噬的诱导至关重要。这篇综述描述了该领域的最新研究以及TOR介导自噬诱导的机制。
