Gingras A C, Raught B, Sonenberg N
Department of Biochemistry, McGill Cancer Centre, McGill University, 3655 Promenade Sir-William-Osler, Montréal, Québec, H3G 1Y6, Canada.
Curr Top Microbiol Immunol. 2004;279:169-97. doi: 10.1007/978-3-642-18930-2_11.
Over the past few years, the target of rapamycin (TOR) pathway has been implicated in the control of translation, both in yeast and in higher eukaryotes. In this review, we provide an overview of translation in eukaryotes, and discuss the mechanisms and advantages of the regulation of translation. We then describe how the TOR pathway can modulate translation in yeast and in mammals, through the modulation of the phosphorylation of key translation components, and the regulation of the abundance of ribosomes and translation factors.
在过去几年中，雷帕霉素靶蛋白（TOR）信号通路已被证实参与酵母和高等真核生物中翻译过程的调控。在这篇综述中，我们概述了真核生物中的翻译过程，并讨论了翻译调控的机制和优势。接着，我们描述了TOR信号通路如何通过调节关键翻译组分的磷酸化以及核糖体和翻译因子的丰度，来调控酵母和哺乳动物中的翻译过程。
