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医源性肝动脉假性动脉瘤:肝脏、胆道和胰腺手术后一种罕见的并发症。

Iatrogenic hepatic artery pseudoaneurysms: an uncommon complication after hepatic, biliary, and pancreatic procedures.

作者信息

Tessier Deron J, Fowl Richard J, Stone William M, McKusick Michael A, Abbas Maher A, Sarr Michael G, Nagorney David M, Cherry Kenneth J, Gloviczki Peter

机构信息

Department of Surgery, Division of Vascular Surgery, Mayo Clinic Scottsdale, Scottsdale, AZ 85259, USA.

出版信息

Ann Vasc Surg. 2003 Nov;17(6):663-9. doi: 10.1007/s10016-003-0075-1. Epub 2003 Oct 23.

Abstract

Hepatic artery pseudoaneurysms are uncommon but potentially lethal complications of hepatic, biliary, and pancreatic interventions. To enhance our knowledge about these pseudoaneurysms, we reviewed our institution's experience with the management of these lesions. We reviewed the literature on 136 cases of hepatic artery pseudoaneurysms as well as our experience with 17 patients (excluding patients who were post-transplantation or had suffered abdominal trauma). The causes, pathogenesis, and clinical features were analyzed. Ten women and seven men developed hepatic artery pseudoaneurysms after undergoing hepatic (65%), biliary (30%), or pancreatic procedures (5%). The mean time between initial intervention and diagnosis was 5.7 months (range 7 days-38 months). Rupture occurred in 13 patients (76%). Mean pseudoaneurysm size was 1.9 cm (range 0.7-4 cm). Embolization was successful in 12 of 14 patients (86%). Four patients (24%), including the two who failed embolization, required operative intervention. Postoperative mortality was 25% while postembolization mortality was 14%. One patient was observed, and the aneurysm thrombosed at 72 months follow-up. Mean follow-up was 48 months (range 1-184 months) for 13 of the 14 survivors (93%) (1 patient was lost to follow-up) without any clinical sequela. Hepatic artery pseudoaneurysms are rare. Rupture is common and occurred in 76% of patients. For both ruptured and nonruptured cases angiography with embolization of the pseudoaneurysm is safe and effective. Operative intervention should be reserved for patients for whom embolization fails or for whom it is not feasible.

摘要

肝动脉假性动脉瘤虽不常见,但却是肝脏、胆道和胰腺介入治疗中潜在的致命并发症。为增进我们对这些假性动脉瘤的了解,我们回顾了本机构处理这些病变的经验。我们查阅了136例肝动脉假性动脉瘤的文献以及我们对17例患者(不包括移植后或腹部外伤患者)的经验。分析了其病因、发病机制及临床特征。10名女性和7名男性在接受肝脏(65%)、胆道(30%)或胰腺手术(5%)后发生肝动脉假性动脉瘤。初次介入与诊断之间的平均时间为5.7个月(范围7天至38个月)。13例患者(76%)发生破裂。假性动脉瘤平均大小为1.9厘米(范围0.7至4厘米)。14例患者中有12例(86%)栓塞成功。4例患者(24%),包括2例栓塞失败的患者,需要手术干预。术后死亡率为25%,栓塞后死亡率为14%。观察了1例患者,在72个月随访时动脉瘤血栓形成。14名幸存者中有13名(93%)平均随访48个月(范围1至184个月)(1例失访),无任何临床后遗症。肝动脉假性动脉瘤罕见。破裂常见,76%的患者发生破裂。对于破裂和未破裂病例,对假性动脉瘤进行血管造影并栓塞是安全有效的。手术干预应保留给栓塞失败或不可行的患者。

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