Armentia A, Arranz M, Martin J M, de la Fuente R, Sanchez P, Barber D, Salcedo G, Blanco A
Unidad de Alergia Hospital Rio Hortega, Valladolid, Spain.
Ann Allergy. 1992 Nov;69(5):441-4.
Inhalant food allergy has been described many times in literature, but double-blind clinical trials to support successful hyposensitization to these allergens has seldom been reported. Some authors have suspected that certain adverse reactions after immunotherapy may be mediated by immune complexes. Furthermore, the FDA does not recommend injection therapy with food extracts. We present a study on the detection of adverse effects after immunotherapy with an inhalant food (wheat flour) in a double-blind clinical trial in 26 patients with bakers' asthma. We investigated the presence of circulating immune complexes (CICs) after 2 years of treatment with hyposensitization to wheat flour.
吸入性食物过敏在文献中已有多次描述，但支持对这些过敏原成功进行减敏治疗的双盲临床试验却鲜有报道。一些作者怀疑免疫疗法后的某些不良反应可能由免疫复合物介导。此外，美国食品药品监督管理局不推荐使用食物提取物进行注射治疗。我们在一项针对26名面包师哮喘患者的双盲临床试验中，开展了一项关于吸入性食物（小麦粉）免疫治疗后不良反应检测的研究。我们对26名面包师哮喘患者进行了为期2年的小麦粉减敏治疗，并检测了循环免疫复合物（CIC）的存在情况。
