Stannylation approach to the synthesis of 2'- and 3'-substituted analogues of 2',3'-didehydro-2',3'-dideoxynucleosides.
作者信息
Kumamoto Hiroki, Onuma Sayoko, Tanaka Hiromichi
机构信息
School of Pharmaceutical Sciences, Showa University, Shinagawa-ku, Tokyo, Japan.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):767-9. doi: 10.1081/NCN-120022630.
PMID:14565274
Abstract
Three methods are described for the introduction of a tributylstannyl group to the sp2-carbon of 2',3'-didehydro-2',3'-dideoxy nucleosides (d44Ns). The resulting stannylated products serve as versatile intermediates for the synthesis of d4Ns having various types of carbon-substituent.
摘要
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