d4TMP delivery from 7-substituted cycloSal-d4TMPs.
作者信息
Meier C, Renze J T, Balzarini J, De Clercq E
机构信息
Institute of Organic Chemistry, University of Hamburg, Hamburg, Germany.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):825-7. doi: 10.1081/NCN-120022663.
PMID:14565288
Abstract
Benzyl-substituted cycloSal-d4T monophosphates were prepared and evaluated for their ability to release d4TMP selectively. In contrast to previously reported derivatives, two of the new compounds release d4TMP as the sole product while two others gave the expected benzyl phosphate diesters. However, these diesters were surprisingly stable against degradation to release d4TMP.
摘要
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