Synthesis and biological evaluation of a series of new cyclohexenyl nucleosides.
作者信息
Gu Ping, Morral Jordi, Wang Jing, Rozenski Jef, Busson Roger, Van Aerschot Arthur, De Clercq Erik, Herdewijn Piet
机构信息
Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):845-7. doi: 10.1081/NCN-120022668.
PMID:14565293
Abstract
A series of cyclohexenyl nucleosides (1-8) were successfully prepared with moderate yield and their cytotoxicity and antiviral activity were investigated. Among the eight new compounds, only the diaminopurine analogue 8 showed pronounced activity against HSV-1, HSV-2.
摘要
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