Gu Ping, Morral Jordi, Wang Jing, Rozenski Jef, Busson Roger, Van Aerschot Arthur, De Clercq Erik, Herdewijn Piet
Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium.
Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):845-7. doi: 10.1081/NCN-120022668.
A series of cyclohexenyl nucleosides (1-8) were successfully prepared with moderate yield and their cytotoxicity and antiviral activity were investigated. Among the eight new compounds, only the diaminopurine analogue 8 showed pronounced activity against HSV-1, HSV-2.
