硫代核苷酸作为核糖核苷酸还原酶的抑制剂。
Thionucleotides as inhibitors of ribonucleotide reductase.
作者信息
Roy B, Chambert S, Lepoivre M, Décout J L
机构信息
Institut de Biochimie Biophysique Moléculaire et Cellulaire, Université de Paris Sud, UMR CNRS 8619, Orsay, France.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):883-5. doi: 10.1081/NCN-120022677.
PMID:14565302
Abstract
Ribonucleosides and xylonucleosides bearing a disulfide function on the sugar ring were synthesized. Ribonucleosides belonging to the cytidine series were found to efficiently reduce dNTP pools in the human lymphoblastoid CEM/SS cell line.
摘要
合成了在糖环上带有二硫键功能的核糖核苷和木糖核苷。发现属于胞苷系列的核糖核苷能有效降低人淋巴母细胞CEM/SS细胞系中的dNTP池。
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