从天然核苷合成4'-C-乙炔基和4'-C-氰基嘌呤核苷及其抗HIV活性。
Synthesis of 4'-C-ethynyl and 4'-C-cyano purine nucleosides from natural nucleosides and their anti-HIV activity.
作者信息
Kohgo Satoru, Yamada Kohei, Kitano Kenji, Sakata Shinji, Hayakawa Hiroyuki, Nameki Daisuke, Kodama Eiichi, Matsuoka Masao, Mitsuya Hiroaki, Ohrui Hiroshi
机构信息
Biochemicals Division, Yamasa Corporation, Choshi, Chiba, Japan.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):887-9. doi: 10.1081/NCN-120022678.
PMID:14565303
Abstract
Purine 2'-deoxynucleosides bearing an ethynyl or a cyano group at C-4' of the sugar moiety were synthesized from the corresponding 2'-deoxynucleosides. These compounds exhibited very potent anti-HIV activity, and remained active against drug resistant HIV strains.
摘要
在糖部分的C-4'位带有乙炔基或氰基的嘌呤2'-脱氧核苷是由相应的2'-脱氧核苷合成的。这些化合物表现出非常强的抗HIV活性，并且对耐药HIV毒株仍保持活性。
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