具有刚性糖部分的5-氮杂胞苷核苷作为潜在抗肿瘤剂的合成。
Synthesis of 5-azacytidine nucleosides with rigid sugar moiety as potential antitumor agents.
作者信息
Chun Moon Woo, Kim Myong Jung, Kim Hea Ok, Kim Hee-Doo, Kim Joong Hyup, Moon Hyung Ryong, Jeong Lak Shin
机构信息
College of Pharmacy, Seoul National University, Seoul, Korea.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):915-7. doi: 10.1081/NCN-120022685.
PMID:14565310
Abstract
The bicyclic 3'-O,5'-C-methylene-linked and 2'-O,5'-C-methylene-linked 5-azacytidine derivatives were readily synthesized from 1,2;5,6-di-O-isopropylidene-D-glucose and evaluated against several cancer cell lines.
摘要
双环3'-O,5'-C-亚甲基连接和2'-O,5'-C-亚甲基连接的5-氮杂胞苷衍生物可轻松地从1,2;5,6-二-O-异丙叉基-D-葡萄糖合成，并针对几种癌细胞系进行了评估。
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