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用于识别嘧啶 - 嘌呤倒置位点的新型核苷类似物。

New nucleoside analogues for the recognition of pyrimidine-purine inversion sites.

作者信息

Buchini Sabrina, Leumann Christian J

机构信息

Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1199-201. doi: 10.1081/NCN-120022835.

DOI:10.1081/NCN-120022835
PMID:14565379
Abstract

A new nucleoside designed to enhance triplex stability has been synthesised in 15 steps starting from sugar 2. This pathway contains the sugar derivative 9 which is a useful intermediate for the introduction of other natural and unnatural bases into the 2'-aminoethoxy nucleoside containing scaffold.

摘要

一种旨在增强三链体稳定性的新型核苷已从糖2开始经15步合成。该途径包含糖衍生物9，它是将其他天然和非天然碱基引入含2'-氨基乙氧基核苷支架的有用中间体。

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New nucleoside analogues for the recognition of pyrimidine-purine inversion sites.用于识别嘧啶 - 嘌呤倒置位点的新型核苷类似物。
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2
Synthesis and duplex DNA recognition studies of oligonucleotides containing a ureido isoindolin-1-one homo-N-nucleoside. A comparison of host-guest and DNA recognition studies.含脲基异吲哚啉-1-酮同型-N-核苷的寡核苷酸的合成及双链DNA识别研究。主客体研究与DNA识别研究的比较。
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Pyrimidine-purine-pyrimidine triplex DNA stabilization in the presence of tetramine and pentamine analogues of spermine.在精胺的四胺和五胺类似物存在下嘧啶-嘌呤-嘧啶三链DNA的稳定化
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Simple ethers as models of sugar molecules in calculations of vertical excitation energies of DNA and RNA nucleosides.在DNA和RNA核苷垂直激发能计算中作为糖分子模型的简单醚类。
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Modification of the aromatic ring of the WNA analogues for expansion of the triplex recognition codes.对WNA类似物的芳香环进行修饰以扩展三链体识别密码。
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[Polymethylene derivatives of nucleic bases with omega-functional groups. V. Pyrimidine- and purine-containing gamma-butyrophenones].[含ω-官能团的核酸碱基的聚亚甲基衍生物。V. 含嘧啶和嘌呤的γ-丁酰苯]
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[Possible A-conformation and conformation intermediate between the A- and B-forms of DNA fragments with alternating purine-pyrimidine sequences].[具有交替嘌呤-嘧啶序列的DNA片段的可能A构象以及A和B构象之间的构象中间体]
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Synthesis of C-nucleoside analogues based on the pyrimidine skeleton for the formation of anti-parallel-type triplex DNA with a CG mismatch site.基于嘧啶骨架的 C-核苷类似物的合成，用于与 CG 错配位点形成反平行型三链 DNA。
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Combining nucleoside analogues to achieve recognition of oligopurine tracts by triplex-forming oligonucleotides at physiological pH.在生理pH值下，联合核苷类似物以实现三链形成寡核苷酸对寡嘌呤序列的识别。
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Effects of the modified aromatic ring of WNA on stability of triplex DNA.WNA修饰的芳香环对三链DNA稳定性的影响。
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Cross-linking to an interrupted polypurine sequence with a platinum-modified triplex-forming oligonucleotide.通过铂修饰的三链形成寡核苷酸与中断的聚嘌呤序列交联。
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