用于寡核糖核苷酸合成的6-硫代鸟苷亚磷酰胺的制备。
Preparation of 6-thioguanosine phosphoramidite for oligoribonucleotide synthesis.
作者信息
Wang Yang, Lattmann Eric, Zheng Qinguo
机构信息
School of Life and Health Sciences, Aston University, Birmingham, England.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1247-9. doi: 10.1081/NCN-120022847.
PMID:14565391
Abstract
6-Thioguanosine phosphoramidite was prepared, using 2,4-dinitrophenyl as protection group for thio-function, and its stability towards conditions of RNA synthesis was investigated. The results show that the monomer was stable under the conditions of RNA synthesis and suitable for incorporation of thioguanine into oligoribonucleotides.
摘要
以2,4-二硝基苯基作为硫醇官能团的保护基团，制备了6-硫代鸟苷亚磷酰胺，并研究了其在RNA合成条件下的稳定性。结果表明，该单体在RNA合成条件下稳定，适用于将硫代鸟嘌呤掺入寡核糖核苷酸中。
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