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2'-O,4'-C-ethylene-bridged nucleic acid (ENA) for effective antisense formation.

作者信息

Morita Koji, Yamate Koji, Kurakata Shin-ichi, Watanabe Kenji, Imanishi Takeshi, Koizumi Makoto

机构信息

Exploratory Chemistry Research Laboratories, Sankyo Co., Limited, Tokyo, Japan.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1619-21. doi: 10.1081/NCN-120023082.

DOI:10.1081/NCN-120023082
PMID:14565480
Abstract

ENA antisense oligonucleotides for vascular endothelial growth factor (VEGF) mRNA were synthesized and evaluated in A549 lung cancer cells. It was found that the VEGF ENA-antisense inhibited not only the expression of VEGF, but also the expression of three genes, which were found in Genbank by BLAST and Clustal W search and considered likely to bind to the VEGF ENA-antisense. These results indicate that ENA-antisense oligonucleotides act in a sequence-specific manner, and could be used as effective antisense drugs.

摘要

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