核碱基的N-磺酰基衍生物和磺酰胺基核苷衍生物的合成及其抗肿瘤活性
Synthesis and antitumor activity of N-sulfonyl derivatives of nucleobases and sulfonamido nucleoside derivatives.
作者信息
Zinić B, Krizmanić I, Glavas-Obrovac Lj, Karner I, Zinić M
机构信息
Ruder Bosković Institute, Zagreb, Croatia.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1623-5. doi: 10.1081/NCN-120023084.
PMID:14565481
Abstract
The introduction of sulfonamido group on the C-2 position of pyrimidine nucleosides was achieved by ring opening of 2,2'- and 2,3'-anhydronucleosides. N-sulfonyl derivatives of nucleobases and sulfonamido derivatives of nucleosides were assayed for in vitro antitumor activity.
摘要
通过2,2'-和2,3'-脱水核苷的开环反应，在嘧啶核苷的C-2位引入了磺酰胺基。对核苷酸碱基的N-磺酰基衍生物和核苷的磺酰胺基衍生物进行了体外抗肿瘤活性测定。
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