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印度南部急性风湿热和心瓣炎的当前概况。

Current profile of acute rheumatic fever and valvulitis in southern India.

作者信息

Chockalingam Anand, Gnanavelu G, Elangovan S, Chockalingam V

机构信息

Institute of Cardiology, Madras Medical College and Research Institute, Chennai, India.

出版信息

J Heart Valve Dis. 2003 Sep;12(5):573-6.

Abstract

BACKGROUND AND AIM OF THE STUDY

Rheumatic fever (RF) incidence has declined dramatically in the West, but still accounts for a major percentage of cardiac debility in developing countries. The study aim was to analyze the incidence, clinical profile and echocardiography findings in acute RF over the past decade.

METHODS

The records of acute RF admissions to a tertiary care medical college hospital in southern India during the past 10 years were analyzed retrospectively. Chronic rheumatic heart disease and recurrence of RF were excluded from the study. Patients with a first episode of acute RF were studied only if the case records were available, and basic laboratory and echocardiography studies were completed. Thus, a total of 163 patients (81 males, 82 females) qualified for the study.

RESULTS

There was no significant decline in the annual incidence of the first episode of acute RE The most common presenting symptoms were arthralgiaarthritis (n = 157), fever (n = 137) and breathlessness (n = 81). Carditis (67.5%) and arthritis (44.2%) were the most often-reported Jones criteria. Trivial to mild mitral regurgitation by echocardiography occurred in 81%, followed by significant mitral regurgitation in 5.5% and mild aortic regurgitation in 25%. The 'youngest' and 'oldest' first episodes of RF were recorded at ages of 2 and 29 years, respectively.

CONCLUSION

The incidence of RF in India does not show the declining trends of the Western world. The application of Jones criteria for diagnosis remains relevant, though echocardiography is increasingly called upon to 'confirm' clinical diagnosis and help manage these patients in an appropriate manner.

摘要

研究背景与目的

风湿热(RF)在西方的发病率已大幅下降,但在发展中国家仍占心脏衰弱的很大比例。本研究旨在分析过去十年中急性风湿热的发病率、临床特征及超声心动图检查结果。

方法

回顾性分析印度南部一家三级医疗医学院附属医院过去10年急性风湿热入院患者的记录。本研究排除慢性风湿性心脏病和风湿热复发患者。仅当病例记录完整且完成基本实验室检查和超声心动图检查时,才对首次发作急性风湿热的患者进行研究。因此,共有163例患者(81例男性,82例女性)符合研究条件。

结果

急性风湿热首次发作的年发病率无显著下降。最常见的症状为关节痛/关节炎(n = 157)、发热(n = 137)和呼吸困难(n = 81)。心脏炎(67.5%)和关节炎(44.2%)是最常报告的琼斯标准。超声心动图显示轻度至中度二尖瓣反流的发生率为81%,其次重度二尖瓣反流为5.5%,轻度主动脉反流为25%。风湿热首次发作的“最小”和“最大”年龄分别为2岁和29岁。

结论

印度风湿热的发病率未呈现西方世界那样的下降趋势。尽管越来越多地需要超声心动图来“确认”临床诊断并以适当方式帮助管理这些患者,但琼斯标准在诊断中的应用仍然具有相关性。

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